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Common and Unique Boundaries. (A) Illustration of common and unique boundaries. (B) Overlap of TD boundaries identified by the DI method versus TopDom (top) and HiCseg versus TopDom (bottom). Most TD boundaries identified by the DI and HiCseg methods are included in the set identified by TopDom. (C) Overlap of TD boundaries in different cell types (hESC versus IMR90, mESC versus cortex). The TD sets overlap greatly, indicating the strong conservation of TDs across cell types.
