This figure shows the sensitivity of incremental cost-effectiveness ratios to rapid OA progression for Tanezumab added to the standard of care. The figure shows the impact of drug cost ($200 – $1000 per dose), mode and setting of delivery (SC vs IV, self-administered vs non-hospital vs hospital), and rate of rapid OA progression, indicated as ‘toxicity’ (1%, 3%, 5%, 10%). All other variables in this analysis were set to base case values.