Table 1.
Confirmed Primary Hits against KSHV Pr
| Structure | Fragment ID |
KSHV Pr IC50 (µM) |
HCMV Pr IC50 (µM) |
KSHV Pr DD?[a] |
|---|---|---|---|---|
 |
1 | 51.2 | 154 | Yes |
 |
2 | 404 | 199 | Yes |
 |
3 | 495 | > 500 | Yes |
 |
4 | 187 | ---[b] | Yes |
 |
5 | 337 | ---[b] | Yes |
 |
6 | 421 | 954 | Yes |
 |
7 | > 500 | > 500 | Yes |
 |
8 | 81.7 | 179 | Yes |
 |
9 | 89.5 | 261 | Yes |
 |
10 | 197 | ---[b] | Data not acquired |
 |
11 | > 500 | > 500 | Data not acquired |
 |
12 | 445 | > 500 | Yes |
 |
13 | 338 | 199 | No |
 |
14 | 387 | > 500 | Yes |
 |
15 | 337 | 300 | Yes |
 |
16 | 367 | > 500 | Yes |
 |
17 | 235 | > 500 | Yes |
 |
18 | 405 | > 500 | Data not acquired |
 |
19 Negative control |
> 1000 | ---[b] | No |
[a]
Dimer Disruption: determined by reduced 13C-Met Dimer-to-Monomer HSQC peak ratios.
[b]
No quantifiable inhibition.