Table 2.

Comparisons of additional outcomes by different doses of pharmacologic treatments

Reference	Interventions	Mood	Quality of life	Additional side effectsa	Time to hot flash improvement
Barton et al. [12]	Citalopram 10, 20 or 30 mg daily	↔	N/A	↔	↔
Loprinzi et al. [14]	Extended-release venlafaxine 37.5, 75 or 150 mg daily	↔	↔	Venlafaxine 150 mg: ↑ mouth dryness	↔
Pandya et al. [16]	Gabapentin 300 or 900 mg daily	↔	N/A	↔	↔
Stearns et al. [17]	Paroxetine 10 or 20 mg daily	↔	↔	Paroxetine 20 mg: ↑nausea, ↑ study withdrawal	↔

↔ no difference among groups, ↑ increased, ↓, decreased, N/A not assessed

^aOnly additional outcomes that were statistically significantly different among hot flash treatment groups are presented