. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Breast Cancer Res Treat. 2016 Mar 26;156(3):415–426. doi: 10.1007/s10549-016-3765-4

Table 4.

Comparison of outcomes of non-pharmacologic and pharmacologic treatments

Reference	Intervention	Hot flashes	Quality of life	Additional side effects^a	Time to hot flash improvement
Biglia et al. [37]	Gabapentin 900 mg daily or vitamin E 800 IU daily	Favors gabapentin	Favors gabapentin	Gabapentin: ↑sleep quality, ↑dizziness	Favors gabapentin
MacLaughlan David et al. [38]	Gabapentin 900 mg daily or hypnotic inductions (weekly for 3 weeks)	↔	N/A	N/A	↔
Mao et al. [25]	Gabapentin 900 mg daily or electroacupuncture 1-2 times weekly	↔ during active treatment Electroacupuncture with longer durability of effect	N/A	Gabapentin: ↑dizziness, ↑fatigue, ↑drowsiness Electroacupuncture: ↑bruising	↔
Othman et al. [39]	Pregabalin 150 mg daily or stellate ganglion block once	Favors stellate ganglion block	N/A	Stellate ganglion block: Transient Horner's Syndrome Pregabalin: ↑dizziness	↔
Walker et al. [40]	Venlafaxine 75 mg daily or acupuncture 1-2 times weekly	↔ during active treatment Acupuncture with longer durability of effect	↔	Venlafaxine: ↑nausea, ↑headache, ↓sleep quality, ↑dizziness	↔

↔ no difference among groups, ↑ increased, ↓, decreased, N/A not assessed

Only outcomes that were statistically significantly different among hot flash treatment groups are presented