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. Author manuscript; available in PMC: 2016 Apr 20.
Published in final edited form as: Cell Rep. 2016 Apr 7;15(3):588–598. doi: 10.1016/j.celrep.2016.03.046

Figure 5. Identification of Hsp90 mutants that differentially impact the maturation of GR and v-src.

Figure 5

(A) Structural representation of the N-domain of Hsp90 indicating mutations identified as having a strong potential for separation of function. (B) The effects of individually cloned Hsp90 variants on activation of GR and v-src compared to effects on yeast growth rate. (C) Comparison of the effects of Hsp90 mutants on activation efficiency for GR versus v-src identifies eight mutations with severe deficiency for v-src that are capable of mediating the efficient activation of GR. (D) Structural representation of the N-domain of Hsp90 and the Cdc37 co-chaperone based on 1US7.PDB (Roe et al., 2004) indicating the location of the sites of mutations that caused client-specific effects. See also Figure S6.