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. Author manuscript; available in PMC: 2016 Apr 20.
Published in final edited form as: Cell Rep. 2016 Apr 7;15(3):588–598. doi: 10.1016/j.celrep.2016.03.046

Figure 6. Distinct impact of Hsp90 mutations on maturation of v-src and Ste11 kinases.

Figure 6

(A) Comparison of the effects of Hsp90 mutants on activation efficiency for Ste11 versus v-src. Hsp90 mutations with severe defects for v-src activation exhibited impacts on Ste11 activation that ranged from severe defects (colored pink) to intermediate defects (colored orange) to no observable defect (colored blue). (B) The locations of mutations with severe defects for v-src activation are indicated on the structure of Hsp90 bound to Cdc37. The impacts of these mutations on Ste11 activation are indicated by color as in panel A. The location where nucleotide binds is indicated in green.