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Crystal structure of compound 43 bound to MDM2 (PDB ID: 1T4E). A halogen bond between the iodine and Gln72 is observed. Hydrogen bond between Ser17 and the carboxylic acid moiety and a π – π stacking interaction with His96 and the p-chlorophenyl group. Furthermore, various hydrophobic interactions with Leu54, Gly58, Ile61, Tyr67, Phe91, Val93, Ile99, and Tyr100 are shown.
