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Crystal structure of compound 3 (WK-23) bound to MDM2 (PDB ID: 3LBK). A hydrogen bond between the indole NH group of 3 and the MDM2Leu54 carbonyl oxygen is depicted. The 1-(4-chlorobenzyl) group undergoes a T-shaped π–π stacking with His96. The compound makes multiple hydrophobic interactions with Leu57, Gli58, Ile61, Met62, Val93, His96, Ile99, and Tyr100.
