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Regulation of NK cell activity. CDK8-mediated STAT1–Ser727 phosphorylation inhibits the cytolytic activity of NK cells. Similarly, Cbl-b-mediated ubiquitinylation of the TAM receptor results in reduced perforin, granzyme B (red granules), and IFN-γ secretion. TGF-β signaling reduces as well NK cell effector function and leads to downregulation of activating receptors (dotted receptor).
