Table 1.

Summary of main studies linking GBA and PD.

Links between mutant GBA and PD	References
Subset of GD patients develop parkinsonism	Bembi et al. (2003), Neudorfer et al. (1996), Tayebi et al. (2001)
Genetic multi-centre study reporting statistically significant association between GBA mutations and PD	Sidransky et al. (2009)
Lewy bodies similar in PD brains with and without GBA mutations	Neumann et al. (2009), Parkkinen et al. (2011)
Accumulation and impaired turnover of α-synuclein in animal and cell models of GCase deficiency	Cullen et al. (2011), Fishbein et al. (2014), Manning-Boğ et al. (2009), Mazzulli et al. (2011), Osellame et al. (2013), Sardi et al. (2011), Schöndorf et al. (2014)
GCase activity decreased in sporadic PD	Gegg et al. (2012), Murphy et al. (2014)
α-synuclein affects GCase function	Gegg et al. (2012), Mazzulli et al. (2011), Sardi et al. (2013), Yap et al. (2011)