Table 1.

Outline and timelines of the assessments

	Before randomisation	Intervention period (1–24 weeks after randomisation)		Follow-up period (25–36 weeks after randomisation)	After randomisation
Item	− 2 to −1 week	9 weeks	17 weeks	25 weeks	37 weeks
Eligible assessment
Diagnostic criteria	×
Inclusion criteria	×
Exclusion criteria	×
Baseline measurement	×
Primary outcomes
Global cognitive function	×	×	×	×	×
Secondary outcomes
Memory	×	×	×	×	×
Attention	×	×	×	×	×
Processing speed	×	×	×	×	×
Execution	×	×	×	×	×
Verbal learning and memory	×	×	×	×	×
Structure and function of related brain regions	×			×	×
Cerebrovascular function	×			×	×
Quality of life	×			×	×
Adverse events					×

The×indicates at which point of the trial the respective assessments will take place.