Table 1.
Probability parameters used in the analysis
| Probability parameters | Distribution | Parameters |
|---|---|---|
| LNG-IUS | ||
| LNG-IUS to asymptomatic on LNG-IUS | β | (3,2) |
| LNG-IUS to symptomatic on LNG-IUS | β | (3,2) |
| Remain asymptomatic on LNG-IUS | Fixed | 1 |
| Remain asymptomatic off treatment | Fixed | 1 |
| Remain symptomatic on LNG-IUS (<12 months) | Fixed | 1 |
| Remain symptomatic on LNG-IUS (>12 months) | Dirichlet | 8 |
| Symptomatic with LNG-IUS to symptomatic off treatment | 20 | |
| Symptomatic with LNG-IUS to change treatment (hormonal) | 16 | |
| Symptomatic with LNG-IUS to hysterectomy | 4 | |
| Symptomatic with LNG-IUS to conservative surgery | 2 | |
| Remain symptomatic off treatment (<6 months) | Fixed | 1 |
| Remain symptomatic off treatment (>6 months) | Dirichlet | 6 |
| Symptomatic off treatment to asymptomatic off treatment | 2 | |
| Symptomatic off treatment to change treatment (hormonal) | 10 | |
| Change treatment (hormonal) to asymptomatic on 2nd treatment | β | (3,2) |
| Change treatment (hormonal) to symptomatic on 2nd treatment | β | (3,2) |
| Remain asymptomatic on 2nd treatment (<6 months) | 1 | Fixed |
| Remain asymptomatic on 2nd treatment (>6 months) | β | (3,2) |
| Asymptomatic on 2nd treatment to asymptomatic off treatment | β | (3,2) |
| Remain symptomatic on 2nd treatment (<6 months) | Fixed | 1 |
| Remain symptomatic on 2nd treatment (>6 months) | Dirichlet | 6 |
| Symptomatic on 2nd treatment to 2nd conservative surgery | 10 | |
| Symptomatic on 2nd treatment to hysterectomy | 2 | |
| 2nd conservative surgery to symptomatic post-conservative surgery | β | (3,2) |
| 2nd conservative surgery to asymptomatic post-conservative surgery | β | (3,2) |
| Remain symptomatic post-conservative surgery | Fixed | 1 |
| Remain asymptomatic post-conservative surgery | Fixed | 1 |
| Hysterectomy to symptomatic post-hysterectomy | β | (3,2) |
| Hysterectomy to asymptomatic post-hysterectomy | β | (3,2) |
| Remain symptomatic post-hysterectomy | Fixed | 1 |
| Remain asymptomatic post-hysterectomy | Fixed | 1 |
The same principle applies to the transitions for other treatments.
LNG-IUS, levonorgestrel-releasing intrauterine device.