Table 4.
Odds ratio (OR) and 95% confidence interval (CI) of detection of various colorectal neoplasm using colonoscopy as a gold standard by different positive combinations of double fecal immunochemical tests (FITs) in the Jiashan mass colorectal cancer (CRC) screening program in China, 2007–2009.
| FIT1 | FIT2 | FITs | Positive | Colonoscopy | Results: n, detection rate, percentagea | |||
|---|---|---|---|---|---|---|---|---|
| n | n | n | CRC | Advanced adenoma | Nonadvanced adenoma | Advanced neoplasm | ||
| + | − | 20,842 | 763 | 619 | 12, 1.9, 30.1 | 37, 6.0, 42.0 | 49, 7.9, 39.8 | 49, 7.9, 38.6 |
| + | + | 20,842 | 301 | 250 | 18, 7.2, 46.2 | 30, 12.0, 34.1 | 24, 9.6, 19.5 | 48, 19.2, 37.8 |
| + | Absent | 3,533 | 84 | 57 | 3, 5.3, 7.7 | 3, 5.3, 3.4 | 5, 8.8, 4.1 | 6, 7.1, 4.7 |
| − | + | 20,842 | 609 | 500 | 6, 1.2, 15.4 | 18, 3.6, 20.5 | 44, 8.8, 35.8 | 24, 4.8, 18.9 |
| Absent | + | 44 | 5 | 4 | 0 | 0 | 1, 25.0, 0.5 | 0 |
| FIT1+b | 24375 | 1,148 | 926 | 33, 3.6, 84.6 | 70, 7.6, 79.5 | 78, 8.4, 63.4 | 103, 11.1, 81.1 | |
| FIT2+c | 20886 | 915 | 754 | 24, 3.2, 61.5 | 48, 6.4, 54.5 | 69, 9.2, 56.1 | 72, 9.5, 56.7 | |
| Total | 24,419 | 1,762 | 1,430 | 39, 2.7, 100.0 | 88, 6.2, 100.0 | 123, 8.6, 100.0 | 127, 8.9, 100.0 | |
| OR (95% CI) of detection rate by FIT (FIT2 versus FIT1) | 0.85 (0.50–1.44) | 0.80 (0.55–1.16) | 1.03 (0.75–1.43) | 0.82 (0.60–1.10) | ||||
| OR (95% CI ) of detection rate by FIT (FITs versus FIT1) | 1.18 (0.74–1.88) | 1.26 (0.92–1.72) | 1.58 (1.19–2.10) | 1.38 (1.07–1.80) | ||||
FIT1, the first FIT; FIT2, the second FIT; FITs, combination of FIT1 and FIT2.
aDetection rate: the number of the colorectal lesions/the number of participants who completed colonoscopy in any combination of FIT1 and FIT2; percentage: the number of the colorectal lesions/the total number of the colorectal lesions in any combination of FIT1 and FIT2.
bReferred to those who completed FIT1 regardless of the completion of FIT2.
cReferred to those who completed FIT2 regardless of the completion of FIT1.