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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Jun 10;85:215–225. doi: 10.1016/j.yjmcc.2015.06.003

Figure 7. Proposed mechanism of Sfrp2/Wnt6/β-Catenin signaling action on CPC proliferation and differentiation.

Figure 7

Sfrp2 binds and inhibits Wnt6 signaling through the canonical pathway leading to cell cycle arrest. This inhibition of canonical pathway activates JNK and non–canonical/PCP downstream pathways which in turn induce expression of cardiac transcription factors priming CPC for differentiation. Sfrp2 binding to Wnt6 could further facilitate binding and activation of non-canonical Wnt signaling (grey font and arrows).