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. Author manuscript; available in PMC: 2016 Apr 21.
Published in final edited form as: J Med Chem. 2016 Jan 29;59(3):1102–1115. doi: 10.1021/acs.jmedchem.5b01696

Figure 5.

Figure 5

HTS screening. 7-DHC (pg/cell) in a 384-well plate of Dhcr7-deficient Neuro2a cells plated (13000 cells/well) on 281 of the 727 compounds in the NIH Clinical Collection. First, 1 µM of a compound was predeposited in each well and then cells were incubated for 24 h at 37 °C. 7-DHC levels expressed as pg/number of cells. The left four entries are for DMSO controls (n = 19) aripiprazole, bazedoxifene, and clomiphene at 200 nM, also shown color-coded with n > 3; ***p < 0.0001.