Figure 5. Inhibition is necessary for light-evoked oscillations.

The pharmacological blockade of GABA_A receptors disinhibited the network and altered quantitatively but not qualitatively the spontaneous activity, significantly (p < 0.05) increasing the burst rate and decreasing the burst duration (A). However, light-evoked responses were qualitatively affected by network disinhibition as they did not contain oscillatory components (n = 17 MEAs), as revealed by the power spectrum analysis (see Fig. 3) and the lack of a dominant oscillation frequency (B,C).