Figure 4. Select circulating miRNAs can identify acute Ebola virus infection in NHPs and humans.

Eight host-derived miRNAs were selected by a support vector machine (SVM) classifier trained on intramuscularly-challenged rhesus macaques (n = 6) to identify EBOV infection. (A) Relative miRNA abundances (ΔCq) are shown for each classifier miRNA, separated by viral load. Individual points are plotted for each sample where the given miRNA was amplifiable, with lines are drawn to show the median value for each cohort. (B) Classifier performance metrics calculated from testing aerosol NHP and human samples combined (n = 43). Performance parameters are described briefly in the main text.