Figure 8. DNase 1 treatment prevents E. carinatus venom-induced tissue destruction in the challenge study.

(a) The graph represents the continued high injury score in E. carinatus venom (LD₅₀)-injected mouse tails (red line), whereas the administration of 100 U DNase 1 at various times (30–180 min post-venom injection) decreased the tail injury score. The data are presented as mean±s.e.m. (n=10). *P<0.05, ***P<0.001 versus PBS injected control mice; one-way analysis of variance, followed by Dunnett's post-hoc test. (b) Representative photographs of mice taken on different days after injection. The mice were injected with E. carinatus venom (LD₅₀; top row) or co-injected with E. carinatus venom (LD₅₀) and DNase 1 (100 U; bottom row); the mice in the latter group recovered and normal tail morphology was restored on day 4 onwards (bottom, third). Scale bars, 2 cm (n=10).