Table 2.
Differences in pregnancy outcomes with early initiation of low-dose aspirin
| Outcome | Aspirin | Placebo | P-value |
|---|---|---|---|
| Overall | N = 265 | N = 258 | |
| Preeclampsia | 59 (22.26) | 71 (27.52) | 0.164 |
| ‘Late’ preeclampsia, delivery ⩾ 34w | 46 (17.36) | 63 (24.42) | 0.047 |
| ‘Early’ preeclampsia, delivery <34w | 13 (4.91) | 8 (3.10) | 0.293 |
| SGA | 15 (5.66) | 23 (8.91) | 0.152 |
| Composite: ‘early’ preeclampsia or SGA | 25 (9.43) | 28 (10.85) | 0.591 |
| Diabetes mellitus | N = 94 | N = 97 | |
| Preeclampsia | 17 (18.09) | 21 (21.65) | 0.537 |
| ‘Late’ preeclampsia, delivery ⩾ 34w | 12 (12.77) | 18 (18.56) | 0.272 |
| ‘Early’ preeclampsia, delivery <34w | 5 (5.32) | 3 (3.09) | 0.443 |
| SGA | 3 (3.19) | 3 (3.09) | 0.969 |
| Composite: ‘early’ preeclampsia or SGA | 7 (7.45) | 6 (6.19) | 0.729 |
| Chronic hypertension | N = 93 | N = 93 | |
| Preeclampsia | 23 (24.73) | 32 (34.41) | 0.148 |
| ‘Late’ preeclampsia, delivery ⩾ 34w | 17 (18.28) | 29 (31.18) | 0.041 |
| ‘Early’ preeclampsia, delivery <34w | 6 (6.45) | 3 (3.23) | 0.305 |
| SGA | 8 (8.60) | 11 (11.83) | 0.468 |
| Composite: ‘early’ preeclampsia or SGA | 13 (13.98) | 12 (12.90) | 0.83 |
| History of preeclampsia | N = 78 | N = 68 | |
| Preeclampsia | 19 (24.36) | 18 (26.47) | 0.77 |
| ‘Late’ preeclampsia, delivery ⩾ 34w | 17 (21.79) | 16 (23.53) | 0.803 |
| ‘Early’ preeclampsia, delivery <34w | 2 (2.56) | 2 (2.94) | 0.889 |
| SGA | 4 (5.13) | 9 (13.24) | 0.086 |
| Composite: ‘early’ preeclampsia or SGA | 5 (6.41) | 10 (14.71) | 0.1 |
Abbreviations: SGA, small for gestational age; w, weeks. We compared outcomes using exact X2-test. Results are presented as n (%). We used X2-test.