Relative risk (RR) of preterm birth (PTB) (<37 weeks) for progesterone vs placebo. Unadjusted RR (open circles) and adjusted RR (closed circles) from binomial regression. Each adjusted model is result of backward selection process that considered: race (black vs otherwise), smoking cigarettes during pregnancy, marital status, maternal age >30 years, years of education, and illicit drug or alcohol use during pregnancy, as well as interactions between smoking and weight/body mass index (BMI), and smoking and treatment as potential covariates. For each adjusted binomial model, >1 previous PTB was only predictor to remain as covariate. Integer weight at which confidence intervals (CI) begin to include RR = 1 was 166 lb in unadjusted model, and 164 lb in model including previous PTB.