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. 2016 Feb 25;1(2):e85817. doi: 10.1172/jci.insight.85817

Figure 4. Doxorubicin-induced mitochondrial abnormalities at day 14.

Figure 4

Transmission electron micrographs of the left ventricle (LV) 14 days after treatment with (A, C, and E) vehicle or (B, D, and F) doxorubicin (DOX) in (A and B) WT, (C and D) humanized heme oxygenase-1 (HO-1) overexpressing (HBAC) mice, or (E and F) mice with cardiac-specific overexpression of HO-1 (cs-HO-1). White arrows depict dilated sarcoplasmic reticulum. (G–I) HO-1 overexpression in cs-HO-1 mice prevents DOX-induced disorganization of intercalated disks (IDs). Original magnification, ×4,400. Scale bar: 2 μm. n = 3–5 mice per group, with at least 5 images evaluated per mouse. Images were assessed by a reviewer blinded to the different groups.