Table 1. Gene expression studies of asthma used for the bioinformatics analysis.
| No. | Study |
Affimerix Mouse Array | Mice | Antigen (Mice number) | No. of challenges | Sampling time (hr after last challenge) | |||
|---|---|---|---|---|---|---|---|---|---|
| GSE | GPL | PMID | Comparison | ||||||
| 1 | 13032 | 1261 | 19491150 | A | Genome 430 2.0 | A/J | PBS (3) | 3 | 3 |
| OVA (3) | |||||||||
| B | B6 | PBS (3) | 3 | 3 | |||||
| OVA (3) | |||||||||
| 2 | 6858 | 1261 | 17437023 | C | Genome 430 2.0 | BALB/c | PBS (4) | 7 | 24 |
| OVA (4) | |||||||||
| 3 | 9465 | 1261 | 19057703 | D | Genome 430 2.0 | A/J | PBS (3) | 1 | 96 |
| OVA (3) | |||||||||
| 4 | 1301 | 339–340 | – | E | U74 Version 2 | BALB/c | PBS (3) | 2 | 72 |
| HDM (3) | |||||||||
| 5 | 3184 | 339 | – | F | U74 Version 2 | C3H | PBS (5) | 1 | 6 |
| OVA (5) | |||||||||
| G | C3H | PBS (5) | 1 | 24 | |||||
| OVA (5) | |||||||||
| H | A/J | PBS (5) | 1 | 6 | |||||
| OVA (5) | |||||||||
| I | A/J | PBS (5) | 1 | 24 | |||||
| OVA (5) | |||||||||
| 6 | 18010 | 1261 | 19770271 | J | Genome 430 2.0 | B6.Il4raQ576/Q576 | -(5) | 7 | 24 |
| B6.Il4raQ576/Q576/IL-13tg | IL-13 (8) | ||||||||
Six GEO Datasets (http://www.ncbi.nlm.nih.gov/gds/) studies were selected for meta-analysis on the basis of the microarray platform and in vivo experimental protocol. From those 6 studies, 10 asthmatic vs. healthy control comparisons (A to J) have been extracted and further analyzed.