Table 4.
Metasummary of motivating factors mentioned by parents for participation of their child in clinical drug research
| Motivating factor | No. of studies (total = 33) | Individual studies |
|---|---|---|
| Personal health benefit for child a | 31 | Barakat, 2013; Baren, 1999; Barrera, 2005; Brody, 2005; Brody, 2012; Buscariollo, 2012; Caldwell, 2003; Cartwright, 2011; Deatrick, 2002; Harth, 1999; Hoberman, 2013; Hoehn, 2005; Lebensburger, 2013; Liaschenko, 2001; MacNeill, 2013; Masiye, 2008; Oppenheim, 2005; Patterson, 2014; Pletsch, 2001; Pletsch, 2001 (2); Read, 2009; Sammons, 2007; Tait, 1998; Tait, 2003; Truong, 2011; Van Stuijvenberg, 1998; Vanhelst, 2013; Wagner, 2006; Woodgate, 2010; Wynn, 2010; Zupancic, 1997 |
| Altruism b | 26 | Baren, 1999; Barrera, 2005; Buscariollo, 2012; Caldwell, 2003; Cartwright, 2011; Deatrick, 2002; Harth, 1999; Hoberman, 2013; Hoehn, 2005; Liaschenko, 2001; MacNeill, 2013; Patterson, 2014; Pletsch, 2001; Pletsch, 2001 (2); Read, 2009; Rothmier, 2003; Sammons, 2007; Tait, 1998; Tait, 2003; Truong, 2011; Van Stuijvenberg, 1998; Vanhelst, 2013; Wendler, 2012; Woodgate, 2010; Wynn, 2010; Zupancic, 1997 |
| Trust in safety of research | 12 | Barakat, 2013; Buscariollo, 2012; Cartwright, 2011; Harth, 1999; Hoberman, 2013; Hoehn, 2005; MacNeill, 2013; Patterson, 2014; Tait, 1998; Truong, 2011; Vanhelst, 2013; Zupancic, 1997 |
| Relation to researcher | 12 | Buscariollo, 2012; Caldwell, 2003; Harth, 1999; Hoberman, 2013; Masiye, 2008; Read, 2009; Sammons, 2007; Tait, 1998; Tait, 2003; Truong, 2011; Woodgate, 2010; Van Stuijvenberg, 1998 |
| More contact with medical team | 8 | Buscariollo, 2012; Caldwell, 2003; Harth, 1999; Lebensburger, 2013; MacNeill, 2013; Masiye, 2008; Wynn, 2010; Woodgate, 2010 |
| Benefit for parents themselves | 5 | Harth, 1999; Oppenheim, 2005; Rothmier, 2003; Wagner, 2006; Van Stuijvenberg, 1998; |
| Minimal burden for child | 4 | Patterson, 2014; Pletsch, 2001 (2); Read, 2009; Woodgate, 2010 |
| Financial reimbursement | 5 | Brody, 2012; Buscariollo, 2012; Harth, 1999; Masiye, 2008; Wagner, 2006 |
| Felt as only option c | 4 | Cartwright, 2011; Deatrick, 2002; Liaschenko, 2001; Oppenheim, 2005 |
| Influence of family and friends | 3 | Buscariollo, 2012; Harth, 1999; Read, 2009 |
a factor mentioned in studies with and without prospect of direct benefit; b In 3 studies specifically defined as no motivating factor; c all studies were in oncology setting