Tab. 1.

Options for vascular risk assessment

Risk category	RF	SCOREa (10-year risk; %)	Framinghamb (10-year risk; %)	Vascular and/or metabolic morbidity
Very high		≥ 10		Manifest coronary heart disease (CHD) Ischemic stroke or transitory ischemic attack (TIA) + evidence for atherosclerosis Peripheral arterial occlusive disease (PAOD) Type 2 diabetes Type 1 diabetes with end-organ damage (EOD; e. g., albuminuria) Moderate to severe nephropathy Progressive or recurrent CHD in spite of LDL‑C < 100 mg/dl
High	> 2	≥ 5	> 20	Familial hypercholesterolemia (FH) Type 1 diabetes + age > 40 years without target-organ disease Distinctly increased individual risk factors (e. g., familial hypertension, severe hypertension)
Moderate	2	1–5	10–20
Low	0–1	< 1	(mostly < 10)

RF risk factor/marker, LDL‑C low-density lipoprotein cholesterol

^a SCORE (Systematic COronary Risk Evaluation) is based on data from 12 European cohort studies with a total of more than 205,000 participants and gives information about the risk of cardiovascular mortality, calculated for 10 years or until age 60 [13]

^bThe Framingham tables are based on data from the Framingham Heart Study with approximately 5,000 participants and provide an estimation of absolute CHD risk over a period of 10 years (relating to the endpoints lethal/nonlethal myocardial infarction and sudden cardiac death) [14]