ACRV1 |
Yes |
Spermatazoa (acrosomes) |
TARDBP (TDP-43) |
Sperm-oolemma binding/penetration |
No |
No |
[29, 31, 109–111] |
CD177 |
Yes |
Neutrophils |
PR3, PECAM1 |
Neutrophil activation |
Yes |
Yes |
[46, 47, 112–114] |
CD59A |
No |
Neurons, T cells, splenic macrophages, spermatids |
MAC Complex |
Complement inhibitor |
Yes |
Yes |
[115–118] |
CD59B |
Yes (as CD59) |
Lymphocytes, granulocytes, platelets, erythrocytes, activated T cells, spermatazoa, splenic macrophages, mature spermatozoa |
C8, C9 |
Complement inhibition, cell-cell adhesion |
Yes |
Yes |
[17, 48, 56, 67, 118–120] |
GML |
Yes |
Cancer cells |
TRP53 |
Apoptosis |
No |
Yes |
[121, 122] |
GML2 |
No |
Hematopoetic stem cells |
Unknown |
Unknown |
No |
Predicted No |
[123] |
GPIHBP1 |
Yes |
Capillary endothelial cells |
LPL |
Chylomicron processing, LPL transport |
Yes |
Yes |
[62, 63, 124] |
LY6A |
No |
Hematopoetic stem cells, B cells, T cells, DCs |
IFN-γ, MMPs |
T cell activation and proliferation controller |
Yes |
Yes |
[28, 125–129] |
LY6A2 |
No |
Unknown |
Unknown |
Unknown |
No |
Predicted Yes |
|
LY6C1 |
No |
T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells |
Type I and II interferons, LFA-1 |
CD8+ T cell migration |
No |
Yes |
[28] |
LY6C2 |
No |
T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells |
Type I and II interferons, LFA-1 |
CD8+ T cell migration |
No |
Yes |
[28] |
LY6D |
Yes |
Keratinocytes, B cells |
Camptothecin, mitomycin C, carboplatin, hydroxyurea, aphidicolin |
Cell adhesion, B cell specification |
No |
Yes |
[130–134] |
LY6E |
Yes |
Myeloid cells, thymocytes |
Retinoic acid, INF1 |
Monocyte inhibitor, T cell development |
No |
Yes |
[135–139] |
LY6F |
No |
Non-lymphoid tissues |
Unknown |
Unknown |
No |
Predicted Yes |
[140] |
LY6G |
No |
Neutrophils, granulocytes |
LTB4, β2-integrins |
Neutrophil recruitment |
No |
Yes |
[28, 109, 141] |
LY6G2 |
No |
Unknown |
Unknown |
Unknown |
No |
Predicted No |
|
LY6G5B |
Yes |
Stomach, placenta |
Unknown |
Unknown |
No |
No |
[142, 143] |
LY6G5C |
Yes |
Testis, fetal liver/spleen/retina/heart/thymus, MS lesions, germinal center B cells, carcinoid lung |
Unknown |
Hematopoietic cell differentiation |
No |
No |
[142, 143] |
LY6G6C |
Yes |
Fibroblasts |
Unknown |
Filipodia functions |
No |
Yes |
[142, 143] |
LY6G6D |
Yes |
Fibroblasts |
Unknown |
Filipodia functions |
No |
Yes |
[142, 143] |
LY6G6E |
No |
Undifferentiated megakaryocyte-like cells |
Unknown |
α4β2 potentiator, cell adhesion and migration |
No |
Yes |
[105, 142] |
LY6G6F |
Yes |
K562 acute myeloblastic leukemia cells |
GRB2, GRB7 |
Unknown |
No |
Predicted No |
[144] |
LY6G6G |
No |
Unknown |
Unknown |
Unknown |
No |
Predicted No |
|
LY6H |
Yes |
Exocrine and endocrine epithelial cells, CNS |
Unknown |
Unknown |
No |
Yes |
[145, 146] |
LY6I |
No |
Monocytes, granulocytes, CD19+ B cells, thymocytes and T cells |
Unknown |
Unknown |
No |
Yes |
[28, 147] |
LY6K |
Yes |
Keratinocytes, squamous cell carcinomas |
JUND, FOSL1, RAS |
Invasive cell metastasis |
Yes |
Yes |
[148–152] |
LY6L |
Yes |
Unknown |
Unknown |
Unknown |
No |
Predicted Yes |
|
LY6M |
No |
Unknown |
Unknown |
Unknown |
No |
Predicted Yes |
|
LYNX1 |
Yes |
CNS neurons |
α4β2 and α7 nAChRs |
nAChR modulator |
Yes |
Yes |
[25, 66, 73, 153] |
LYPD1 |
Yes |
Airway epithelial cells, embryonic tissue, CNS and PNS neurons |
α4β2, α4β4, and α7 nAChRs |
α7 nAChR modulator, tumor suppression |
Yes |
Yes |
[103, 104, 154, 155] |
LYPD2 |
Yes |
Unknown |
α4β2 nAChRs |
nAChR Modulator |
No |
Yes |
[105] |
LYPD3 |
Yes |
Stratum spinosum keratinocytes, cancer cells |
α6β4, MMP14 |
Metastasis, EMT, wound healing |
No |
Yes |
[156–160] |
LYPD4 |
Yes |
Unknown |
Unknown |
Unknown |
No |
Predicted No |
|
LYPD5 |
Yes |
Stratum granulosum keratinocytes |
AP-1 |
Unknown |
No |
Yes |
[156, 161] |
LYPD6 |
Yes |
Ubiquitously |
WNT3A |
Tumor suppression |
No |
Yes |
[162–164] |
LYPD6B |
Yes |
Testis, lung, stomach, prostate |
AP-1 |
PKC signal transduction pathway |
No |
Yes |
[165] |
LYPD8 |
Yes |
Unknown |
Unknown |
Unknown |
No |
Predicted Yes |
|
LYPD9 |
No |
Unknown |
Unknown |
Unknown |
No |
Predicted Yes |
|
LYPD10 |
No |
Unknown |
Unknown |
Unknown |
No |
Predicted Yes |
|
LYPD11 |
No |
Unknown |
Unknown |
Unknown |
No |
Predicted Yes |
|
PATE1 |
Yes |
Leydig cells, testicular germ cells, prostatic epithelial cells principle cells, spermatazoa, |
INCA1 |
Spermatazoa/egg fusion and penetration, spermatazoa motility |
No |
No |
[29, 32, 166–168] |
PATE2 |
Yes |
Spermatazoa, testicular germ cells, neuronal tissue |
nAChR |
nAChR modulator |
No |
No |
[29, 31] |
PATE3 |
Yes |
Testis |
nAChR |
nAChR modulator |
No |
No |
[29] |
PATE4 |
Yes |
Spermatazoa, prostatic apical epithelial cells, spinal cord tissue |
α7 nAChR |
nAChR modulator |
Yes |
No |
[29, 33] |
PATE5 |
No |
Male reproductive organs |
Androgens, lumicrine testicular factors |
Unknown |
No |
No |
[29, 30] |
PATE6 |
No |
Male reproductive organs |
Androgens |
nAChR regulator |
No |
No |
[29, 30] |
PATE7 |
No |
Male reproductive organs |
Androgens |
Unknown |
No |
No |
[29, 30] |
PATE8 |
No |
Male reproductive organs, skeletal muscle |
Androgens |
Unknown |
No |
No |
[29, 30] |
PATE9 |
No |
Male reproductive organs |
Unknown |
Unknown |
No |
No |
[29, 30] |
PATE10 |
No |
Male reproductive organs |
Androgens, lumicrine testicular factors |
Unknown |
No |
No |
[29, 30] |
PATE11 |
No |
Placenta |
α4β2 nAChR |
α4β2 nAChR regulator |
No |
No |
[29, 30] |
PATE12 |
No |
Placenta |
Unknown |
Unknown |
No |
No |
[29, 30] |
PATE13 |
No |
Male reproductive organs |
Androgens |
Unknown |
No |
No |
[29] |
PATE14 |
No |
Luminal epithelium of seminal vesicles |
Androgens |
Unknown |
No |
No |
[169] |
PINLYP |
Yes |
Unknown |
Unknown |
Unknown |
No |
Predicted No |
|
PLAUR |
Yes |
Airway epithelial cells, trophoblast cells, cancerous cells, HUVEC, pan-epithelial |
uPA, Mac-1, caveolin, SERPINE1, vitronectin, kininogen, thrombospondin, α2-macroglobulin receptor, MRC2, cation-independent mannose 6-phosphate/insulin-like growth factor II receptor |
Fibrinolysis, matrix remodeling, cell migration, growth factor activation, integrin regulation, tumor cell invasion, cell adhesion |
Yes |
Yes |
[23, 170–185] |
PSCA |
Yes |
Prostate basal cells, epithelial cells of prostate, urinary bladder, kidney, skin, esophagus, stomach, and placenta, cortical cells |
SNAI2, α4 nAChR |
Tumor suppression, oncogene, nAChR modulator |
Yes |
Yes |
[26, 57–59, 61, 150, 186–188] |
SLURP1 |
Yes |
Keratinocytes, mucocutaneous and aerodigestive epithelia, some C-fiber neurons |
α7 nAChR, KLF4 |
Tumor suppression, nAChR modulator |
Yes |
No |
[20, 76, 79, 94, 99, 189–192] |
SLURP2 |
Yes |
Oral and epidermal keratinocytes |
α3 nAChR |
nAChR modulator, blocks apoptosis |
Yes |
No |
[99–102, 193] |
SPACA4 |
Yes |
Spermatazoa |
Unknown |
Spermatazoa-egg binding/fusion |
No |
Yes |
[194] |
TEX101 |
Yes |
Spermatazoa, cancerous tissues |
Progesterone, PLAU |
Spermatazoaatogenesis, spermatazoa-egg interaction, protease suppressor |
Yes |
Yes |
[151, 195–198] |