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. 2016 Apr 21;10:10. doi: 10.1186/s40246-016-0074-2

Table 3.

Expression patterns, interacting factors and cellular functions of mouse Ly6/uPAR family proteins

Approved protein symbol Human ortholog? Expression pattern Interacting factors Cellular function Gene knockout? GPI-anchor? References
ACRV1 Yes Spermatazoa (acrosomes) TARDBP (TDP-43) Sperm-oolemma binding/penetration No No [29, 31, 109–111]
CD177 Yes Neutrophils PR3, PECAM1 Neutrophil activation Yes Yes [46, 47, 112–114]
CD59A No Neurons, T cells, splenic macrophages, spermatids MAC Complex Complement inhibitor Yes Yes [115–118]
CD59B Yes (as CD59) Lymphocytes, granulocytes, platelets, erythrocytes, activated T cells, spermatazoa, splenic macrophages, mature spermatozoa C8, C9 Complement inhibition, cell-cell adhesion Yes Yes [17, 48, 56, 67, 118–120]
GML Yes Cancer cells TRP53 Apoptosis No Yes [121, 122]
GML2 No Hematopoetic stem cells Unknown Unknown No Predicted No [123]
GPIHBP1 Yes Capillary endothelial cells LPL Chylomicron processing, LPL transport Yes Yes [62, 63, 124]
LY6A No Hematopoetic stem cells, B cells, T cells, DCs IFN-γ, MMPs T cell activation and proliferation controller Yes Yes [28, 125–129]
LY6A2 No Unknown Unknown Unknown No Predicted Yes
LY6C1 No T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells Type I and II interferons, LFA-1 CD8+ T cell migration No Yes [28]
LY6C2 No T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells Type I and II interferons, LFA-1 CD8+ T cell migration No Yes [28]
LY6D Yes Keratinocytes, B cells Camptothecin, mitomycin C, carboplatin, hydroxyurea, aphidicolin Cell adhesion, B cell specification No Yes [130–134]
LY6E Yes Myeloid cells, thymocytes Retinoic acid, INF1 Monocyte inhibitor, T cell development No Yes [135–139]
LY6F No Non-lymphoid tissues Unknown Unknown No Predicted Yes [140]
LY6G No Neutrophils, granulocytes LTB4, β2-integrins Neutrophil recruitment No Yes [28, 109, 141]
LY6G2 No Unknown Unknown Unknown No Predicted No
LY6G5B Yes Stomach, placenta Unknown Unknown No No [142, 143]
LY6G5C Yes Testis, fetal liver/spleen/retina/heart/thymus, MS lesions, germinal center B cells, carcinoid lung Unknown Hematopoietic cell differentiation No No [142, 143]
LY6G6C Yes Fibroblasts Unknown Filipodia functions No Yes [142, 143]
LY6G6D Yes Fibroblasts Unknown Filipodia functions No Yes [142, 143]
LY6G6E No Undifferentiated megakaryocyte-like cells Unknown α4β2 potentiator, cell adhesion and migration No Yes [105, 142]
LY6G6F Yes K562 acute myeloblastic leukemia cells GRB2, GRB7 Unknown No Predicted No [144]
LY6G6G No Unknown Unknown Unknown No Predicted No
LY6H Yes Exocrine and endocrine epithelial cells, CNS Unknown Unknown No Yes [145, 146]
LY6I No Monocytes, granulocytes, CD19+ B cells, thymocytes and T cells Unknown Unknown No Yes [28, 147]
LY6K Yes Keratinocytes, squamous cell carcinomas JUND, FOSL1, RAS Invasive cell metastasis Yes Yes [148–152]
LY6L Yes Unknown Unknown Unknown No Predicted Yes
LY6M No Unknown Unknown Unknown No Predicted Yes
LYNX1 Yes CNS neurons α4β2 and α7 nAChRs nAChR modulator Yes Yes [25, 66, 73, 153]
LYPD1 Yes Airway epithelial cells, embryonic tissue, CNS and PNS neurons α4β2, α4β4, and α7 nAChRs α7 nAChR modulator, tumor suppression Yes Yes [103, 104, 154, 155]
LYPD2 Yes Unknown α4β2 nAChRs nAChR Modulator No Yes [105]
LYPD3 Yes Stratum spinosum keratinocytes, cancer cells α6β4, MMP14 Metastasis, EMT, wound healing No Yes [156–160]
LYPD4 Yes Unknown Unknown Unknown No Predicted No
LYPD5 Yes Stratum granulosum keratinocytes AP-1 Unknown No Yes [156, 161]
LYPD6 Yes Ubiquitously WNT3A Tumor suppression No Yes [162–164]
LYPD6B Yes Testis, lung, stomach, prostate AP-1 PKC signal transduction pathway No Yes [165]
LYPD8 Yes Unknown Unknown Unknown No Predicted Yes
LYPD9 No Unknown Unknown Unknown No Predicted Yes
LYPD10 No Unknown Unknown Unknown No Predicted Yes
LYPD11 No Unknown Unknown Unknown No Predicted Yes
PATE1 Yes Leydig cells, testicular germ cells, prostatic epithelial cells principle cells, spermatazoa, INCA1 Spermatazoa/egg fusion and penetration, spermatazoa motility No No [29, 32, 166–168]
PATE2 Yes Spermatazoa, testicular germ cells, neuronal tissue nAChR nAChR modulator No No [29, 31]
PATE3 Yes Testis nAChR nAChR modulator No No [29]
PATE4 Yes Spermatazoa, prostatic apical epithelial cells, spinal cord tissue α7 nAChR nAChR modulator Yes No [29, 33]
PATE5 No Male reproductive organs Androgens, lumicrine testicular factors Unknown No No [29, 30]
PATE6 No Male reproductive organs Androgens nAChR regulator No No [29, 30]
PATE7 No Male reproductive organs Androgens Unknown No No [29, 30]
PATE8 No Male reproductive organs, skeletal muscle Androgens Unknown No No [29, 30]
PATE9 No Male reproductive organs Unknown Unknown No No [29, 30]
PATE10 No Male reproductive organs Androgens, lumicrine testicular factors Unknown No No [29, 30]
PATE11 No Placenta α4β2 nAChR α4β2 nAChR regulator No No [29, 30]
PATE12 No Placenta Unknown Unknown No No [29, 30]
PATE13 No Male reproductive organs Androgens Unknown No No [29]
PATE14 No Luminal epithelium of seminal vesicles Androgens Unknown No No [169]
PINLYP Yes Unknown Unknown Unknown No Predicted No
PLAUR Yes Airway epithelial cells, trophoblast cells, cancerous cells, HUVEC, pan-epithelial uPA, Mac-1, caveolin, SERPINE1, vitronectin, kininogen, thrombospondin, α2-macroglobulin receptor, MRC2, cation-independent mannose 6-phosphate/insulin-like growth factor II receptor Fibrinolysis, matrix remodeling, cell migration, growth factor activation, integrin regulation, tumor cell invasion, cell adhesion Yes Yes [23, 170–185]
PSCA Yes Prostate basal cells, epithelial cells of prostate, urinary bladder, kidney, skin, esophagus, stomach, and placenta, cortical cells SNAI2, α4 nAChR Tumor suppression, oncogene, nAChR modulator Yes Yes [26, 57–59, 61, 150, 186–188]
SLURP1 Yes Keratinocytes, mucocutaneous and aerodigestive epithelia, some C-fiber neurons α7 nAChR, KLF4 Tumor suppression, nAChR modulator Yes No [20, 76, 79, 94, 99, 189–192]
SLURP2 Yes Oral and epidermal keratinocytes α3 nAChR nAChR modulator, blocks apoptosis Yes No [99–102, 193]
SPACA4 Yes Spermatazoa Unknown Spermatazoa-egg binding/fusion No Yes [194]
TEX101 Yes Spermatazoa, cancerous tissues Progesterone, PLAU Spermatazoaatogenesis, spermatazoa-egg interaction, protease suppressor Yes Yes [151, 195–198]