Table 3.
List of genes with changed expression that are significantly (p < 0.01) over- and under-regulated in patients with NSCLC exposed to wood smoke versus tobacco (five IPA biological functions categories)
| Symbol | Log ratio | p-value | Lipid metabolism | Small mol. bioch. | Mol. transport | Cell morphology | Cell. func. and main. |
|---|---|---|---|---|---|---|---|
| Upregulated genes | |||||||
| HIST1H3I | 0.763 | 9.86E-03 | ✓ | ✓ | ✓ | ||
| DONSON | 0.554 | 3.82E-03 | ✓ | ✓ | ✓ | ||
| ENTPD6 | 0.472 | 2.98E-03 | ✓ | ✓ | ✓ | ||
| RIBC2 | 0.383 | 8.19E-04 | ✓ | ✓ | ✓ | ||
| VASN | 0.286 | 9.15E-03 | ✓ | ✓ | ✓ | ||
| ASL | 0.251 | 3.38E-03 | ✓ | ✓ | ✓ | ||
| DMC1 | 0.165 | 6.49E-03 | ✓ | ✓ | ✓ | ||
| ATP4B | 0.12 | 4.14E-03 | ✓ | ✓ | ✓ | ||
| MEST | 0.601 | 8.79E-03 | ✓ | ✓ | |||
| TMEM184A | 0.34 | 6.13E-03 | ✓ | ✓ | |||
| ATG9A | 0.262 | 6.82E-03 | ✓ | ✓ | |||
| PYCR1 | 0.499 | 8.28E-03 | ✓ | ✓ | |||
| RBM38 | 0.301 | 8.38E-03 | ✓ | ✓ | |||
| HNRNPD | 0.219 | 8.57E-03 | ✓ | ✓ | |||
| ZNF239 | 2.60E-01 | 9.77E-04 | ✓ | ✓ | |||
| Downregulated genes | |||||||
| SPTLC2 | −0.412 | 6.28E-03 | ✓ | ✓ | ✓ | ||
| TBRG1 | −0.374 | 3.42E-03 | ✓ | ✓ | ✓ | ||
| ZNF175 | −0.358 | 8.97E-03 | ✓ | ✓ | ✓ | ||
| ZNF594 | −0.351 | 7.40E-03 | ✓ | ✓ | ✓ | ||
| TEX12 | −0.125 | 7.24E-03 | ✓ | ✓ | ✓ | ||
| SLC16A10 | −0.777 | 9.14E-03 | ✓ | ✓ | |||
| GABARAPL1 | −0.61 | 9.62E-04 | ✓ | ✓ | |||
| PAPPA | −0.516 | 3.63E-04 | ✓ | ✓ | |||
| MED31 | −0.261 | 8.96E-03 | ✓ | ✓ | |||
| NDUFAF1 | −0.254 | 6.22E-03 | ✓ | ✓ | |||
| CCDC144NL | −0.224 | 9.26E-03 | ✓ | ✓ | |||
| CNTN4 | −0.189 | 9.02E-03 | ✓ | ✓ | |||
| NXPE2 | −0.145 | 9.07E-03 | ✓ | ✓ | |||
| RCOR3 | −0.143 | 8.15E-03 | ✓ | ✓ | |||
| SGK1 | −0.718 | 6.48E-03 | ✓ | ✓ | |||
| PTPRG | −0.686 | 2.63E-03 | ✓ | ✓ | |||
| DIO2 | −0.623 | 8.90E-03 | ✓ | ✓ | |||
| RBL2 | −0.369 | 6.19E-03 | ✓ | ✓ | |||
| ARNTL | −0.366 | 9.77E-03 | ✓ | ✓ | |||
| TRAF6 | −0.329 | 6.87E-03 | ✓ | ✓ | |||
| MBP | −0.246 | 4.43E-03 | ✓ | ✓ | |||