Table 3.
Plasma levels of estrone, estrone sulphate and SHBG among 325 never and past users of HRT, who were also current drinkers, as percentage difference in hormonal measurements per 10 g/day in alcohol intake
| Genotype | n (%) | Estrone | P-valueb | Estrone sulphate | P-valueb | SHBG | P-valueb |
|---|---|---|---|---|---|---|---|
| n = 325 | ∆ (95 % CI)a | ∆ (95 % CI)a | ∆ (95 % CI)a | ||||
| rs10519297 | |||||||
| AA | 74 (23) | 2 (−4;9) | 3 (−3;9) | −5 (−11;0) | |||
| AG | 182 (56) | 3 (−1;6) | 0.82 | 3 (0;7) | 0.17 | −6 (−9;-3) | 0.23 |
| GG | 69 (21) | 1 (−5;6) | 4 (0;9) | −3 (−7;2) | |||
| AG + GG | 251 (77) | 2 (−1;5) | 0.54 | 4 (1;6) | 0.08 | −5 (−8;-2) | 0.27 |
| rs749292 | |||||||
| GG | 98 (30) | 3 (−2;7) | 4 (1;8) | −5 (−8;-1) | |||
| AG | 165 (51) | 1 (−3;6) | 0.96 | 3 (0;7) | 0.38 | −6 (−9;-2) | 0.94 |
| AA | 62 (19) | 2 (−5;10) | −1 (−7;6) | 0 (−7;6) | |||
| AG + AA | 227 (70) | 1 (−2;5) | 0.85 | 3 (−1;6) | 0.15 | −5 (−8;-1) | 0.95 |
| rs1062033 | |||||||
| CC | 86 (26) | 1 (−3;6) | 4 (0;8) | −5 (−9;-1) | |||
| CG | 175 (54) | 3 (−1;7) | 0.76 | 4 (0;7) | 0.11 | −5 (−8;-2) | 0.67 |
| GG | 64 (20) | 1 (−6;8) | 1 (−4;7) | −4 (−9;2) | |||
| CG + GG | 239 (74) | 2 (−1;6) | 0.45 | 3 (0;7) | 0.03 | −5 (−8;-2) | 0.90 |
| rs10046 | |||||||
| AA | 85 (26) | 3 (−3;10) | 4 (−2;10) | −7 (−12;-1) | |||
| AG | 173 (53) | 2 (−1;7) | 0.89 | 3 (0;7) | 0.29 | −6 (−9;-3) | 0.06 |
| GG | 67 (21) | 1 (−4;5) | 3 (0;8) | −3 (−7;1) | |||
| AG + GG | 240 (74) | 2 (−1;5) | 0.64 | 3 (1;6) | 0.22 | −5 (−7;-2) | 0.24 |
| rs4646 | |||||||
| CC | 177 (54) | 3 (−2;7) | 4 (0;7) | −4 (−8;-1) | |||
| CA | 129 (40) | 2 (−2;6) | 0.49 | 3 (0;7) | 0.30 | −5 (−8;-2) | 0.87 |
| AA | 19 (6) | −6 (−18;7) | 6 (−5;19) | −8 (−18;4) | |||
| CA + AA | 148 (46) | 1 (−2;5) | 0.41 | 3 (0;7) | 0.14 | −5 (−8;-2) | 0.59 |
| rs6493487 | |||||||
| AA | 192 (59) | 3 (−1;8) | 3 (−1;7) | −5 (−9;-1) | |||
| GA | 125 (39) | 2 (−2;5) | 0.79 | 4 (1;8) | 0.64 | −5 (−8;-2) | 0.60 |
| GG | 8 (2) | −1 (−11;11) | −1 (−10;9) | −5 (−14;5) | |||
| GA + GG | 133 (41) | 1 (−2;5) | 0.79 | 4 (1;7) | 0.97 | −5 (−8;-2) | 0.33 |
| rs2008691 | |||||||
| AA | 210 | 2 (−2;6) | 5 (2;8) | −6 (−9;-3) | |||
| (65) | |||||||
| GA | 106 (32) | 2 (−2;6) | 0.67 | 1 (−2;5) | 0.03 | −4 (−8;0) | 0.41 |
| GG | 9 (3) | 12 (−4;31) | 10 (−3;26) | 6 (−7;22) | |||
| GA + GG | 115 (35) | 2 (−2;7) | 0.70 | 2 (−2;6) | 0.02 | −4 (−7;0) | 0.31 |
| rs3751591 | |||||||
| TT | 232 (72) | 2 (−1;6) | 4 (1;7) | −5 (−8;-2) | |||
| TC | 85 (26) | 1 (−3;6) | 0.78 | 2 (−2;6) | 0.70 | −5 (−8;-1) | 0.90 |
| CC | 8 (2) | 11 (−7;31) | 9 (−6;26) | 10 (−6;28) | |||
| CC vs. TT + TC | 8 (2) | 11 (−7;31) | 0.81 | 9 (−6;26) | 0.74 | 10 (−6;28) | 0.86 |
| rs2445762 | |||||||
| TT | 166 (51) | 2 (−1;6) | 3 (0;6) | −4 (−7;-1) | |||
| TC | 139 (43) | 1 (−3;6) | 0.94 | 5 (1;9) | 0.19 | −6 (−10;-2) | 0.72 |
| CC | 20 (6) | 3 (−9;16) | −2 (−11;8) | −8 (−17;2) | |||
| TC + CC | 159 (49) | 1 (−3;6) | 1.00 | 4 (0;8) | 0.17 | −6 (−10;-3) | 0.61 |
| rs11070844 | |||||||
| CC | 255 (78) | 1 (−2;5) | 3 (0;6) | −4 (−7;-1) | |||
| TC | 66 (21) | 5 (−1;11) | 0.73 | 7 (1;12) | 0.92 | −7 (−12;-3) | 0.06 |
| TT | 4 (1) | 4 (−20;37) | 15 (−9;45) | 11 (−13;42) | |||
| TC + TT | 70 (22) | 5 (−1;11) | 0.42 | 7 (2;12) | 0.74 | −7 (−12;-2) | 0.03 |
SHBG Sex-hormone binding globulin
ΔPercentage difference in hormonal measurements per 10 g/day difference in alcohol intake
aAdjusted for age, smoking (never, past, current) and BMI (kg/m2) at baseline
bP-value for interaction. All interactions were kept in the models in all analyses even though there was no interaction