Table 4.
IRR for BC in relation to the studied polymorphisms among postmenopausal women in the DCH cohort
| n cases (%) | n control (%) | IRRa (95 % CI) | IRRb (95 % CI) | P-valuec | |
|---|---|---|---|---|---|
| (n = 687) | (n = 687) | ||||
| rs10519297 | |||||
| AA | 170 (25) | 174 (25) | 1.00 (ref.) | 1.00 (ref.) | |
| AG | 341 (50) | 361 (53) | 0.98 (0.76–1.27) | 0.94 (0.72–1.23) | 0.15 |
| GG | 176 (25) | 152 (22) | 1.23 (0.90–1.68) | 1.25 (0.91–1.72) | |
| AG + GG | 511 (75) | 513 (54) | 1.05 (0.82–1.34) | 1.03 (0.80–1.32) | 0.83 |
| rs749292 | |||||
| GG | 216 (31) | 203 (30) | 1.00 (ref.) | 1.00 (ref.) | |
| AG | 332 (48) | 352 (51) | 0.89 (0.69–1.14) | 0.89 (0.69–1.16) | 0.62 |
| AA | 139 (20) | 132 (19) | 0.97 (0.71–1.33) | 0.99 (0.72–1.37) | |
| AG + AA | 471 (68) | 484 (70) | 0.91 (0.72–1.15) | 0.92 (0.72–1.17) | 0.50 |
| rs1062033 | |||||
| CC | 203 (30) | 186 (27) | 1.00 (ref.) | 1.00 (ref.) | |
| CG | 333 (48) | 354 (52) | 0.85 (0.66–1.10) | 0.85 (0.65–1.11) | 0.46 |
| GG | 151 (22) | 147 (21) | 0.92 (0.67–1.25) | 0.94 (0.68–1.28) | |
| CG + GG | 484 (70) | 501 (73) | 0.87 (0.68–1.11) | 0.88 (0.68–1.12) | 0.30 |
| rs10046 | |||||
| AA | 182 (27) | 188 (28) | 1.00 (ref.) | 1.00 (ref.) | |
| AG | 346 (50) | 353 (51) | 1.02 (0.79–1.31) | 0.97 (0.75–1.26) | 0.52 |
| GG | 159 (23) | 146 (21) | 1.16 (0.85–1.57) | 1.15 (0.84–1.57) | |
| AG + GG | 505 (73) | 499 (72) | 1.06 (0.84–1.34) | 1.02 (0.80–1.31) | 0.86 |
| rs4646 | |||||
| CC | 372 (54) | 371 (54) | 1.00 (ref.) | 1.00 (ref.) | |
| CA | 265 (39) | 262 (38) | 1.00 (0.80–1.25) | 0.97 (0.77–1.21) | 0.95 |
| AA | 50 (7) | 54 (8) | 0.96 (0.63–1.45) | 1.00 (0.65–1.53) | |
| CA + AA | 315 (46) | 316 (46) | 0.99 (0.81–1.22) | 0.97 (0.78–1.20) | 0.78 |
| rs6493487 | |||||
| AA | 407 (59) | 430 (62) | 1.00 (ref.) | 1.00 (ref.) | |
| GA | 245 (36) | 218 (32) | 1.23 (0.98–1.55) | 1.24 (0.98–1.58) | 0.16 |
| GG | 35 (5) | 39 (6) | 0.96 (0.60–1.54) | 0.88 (0.54–1.44) | |
| GA + GG | 280 (40) | 257 (38) | 1.19 (0.95–1.48) | 1.18 (0.94–1.48) | 0.16 |
| rs2008691 | |||||
| AA | 479 (70) | 470 (68) | 1.00 (ref.) | 1.00 (ref.) | |
| GA | 179 (26) | 198 (29) | 0.88 (0.69–1.11) | 0.88 (0.69–1.12) | 0.25 |
| GG | 29 (4) | 19 (3) | 1.43 (0.80–2.57) | 1.45 (0.80–2.64) | |
| GA + GG | 208 (30) | 217 (32) | 0.93 (0.74–1.17) | 0.93 (0.74–1.18) | 0.57 |
| rs3751591 | |||||
| TT | 479 (70) | 498 (72) | 1.00 (ref.) | 1.00 (ref.) | |
| TC | 182 (26) | 176 (26) | 1.07 (0.84–1.36) | 1.07 (0.83–1.37) | 0.60 |
| CC | 26 (4) | 13 (2) | 2.13 (1.04–4.39) | 2.12 (1.02–4.43) | 0.04 |
| TC + CC | 208 (30) | 189 (28) | 1.13 (0.89–1.42) | 1.13 (0.89–1.44) | 0.31 |
| CC vs. TT + TCd | 26 (4) | 13 (2) | 2.09 (1.02–4.29) | 2.09 (1.00–4.34) | 0.05 |
| rs2445762 | |||||
| TT | 359 (52) | 365 (53) | 1.00 (ref.) | 1.00 (ref.) | |
| TC | 278 (40) | 276 (40) | 1.02 (0.81–1.27) | 1.04 (0.83–1.31) | 0.74 |
| CC | 50 (8) | 46 (7) | 1.10 (0.72–1.69) | 1.19 (0.76–1.85) | |
| TC + CC | 328 (48) | 322 (47) | 1.03 (0.83–1.27) | 1.06 (0.85–1.32) | 0.61 |
| rs11070844 | |||||
| CC | 552 (80) | 556 (81) | 1.00 (ref.) | 1.00 (ref.) | |
| TC | 129 (19) | 125 (18) | 1.06 (0.801–1.39) | 1.06 (0.80–1.40) | 0.88 |
| TT | 6 (1) | 6 (1) | 1.01 (0.33–3.13) | 0.86 (0.27–2.73) | |
| TC + TT | 135 (20) | 131 (19) | 1.06 (0.81–1.38) | 1.05 (0.80–1.38) | 0.73 |
aCrude
bAdjusted for parous/nulliparous, number of births, age at first birth, length of school education (low, medium, high), duration of HRT use (years), BMI (kg/m2) and alcohol intake (10 g/day)
c P-value for trend
dCC versus TT and TC