Table 3.

Clinical Global Impression-Improvement scale score, NAC vs. placebo

	Groups				Test of differences
	NAC		Placebo
	n/total	%	n/total	%	Chi-squarea
Week 4					0.28
Response	4/15	26.7	5/14	35.7
No response	11/15	73.3	9/14	64.3
Week 8					0.07
Response	5/13	38.5	4/12	33.3
No response	8/13	61.5	8/12	66.7
Week 12					0.15
Response	6/12	50.0	5/11	45.5
No response	6/12	50.0	6/11	54.5

^aOne-tailed significance ⁺ p < .10; *p < .05. No p values for these chi-squares reached significance at .05 and ranged from .60 to .79

Response = very much improved (1) or much improved (2); no response = minimally improved (3), no change (4), minimally worse (5); no participants scored much worse (6) or very much worse (7)

NAC N-acetylcysteine