Table 2.

Analysis of pairs of killing curves for M. tuberculosis Uganda II vs. Beijing, and M. tuberculosis Uganda II vs. Delhi/CAS

		1x MIC (Ug-0.5 μg/ml, Be-0.03 μg/ml, Ce-0.03 μg/ml)	2x MIC (Ug-1 μg/ml, Be-0.06 μg/ml, Ce-0.24 μg/ml)	5x MIC (Ug-0.25 μg/ml, Be-0.15 μg/ml, Ce-0.15 μg/ml)
Drug (condition)	Strain	p-value, mean of diffs (95 % CI)	p-value, mean of diffs (95 % CI)	p-value, mean of diffs (95 % CI)
INH (aerobic)	Ug vs Be	0.30, −0.191 (−0.623–0.241)	0.40, −0.034 (−0.133–0.635)	0.33, −0.176 (−0.602–0.250)
	Ug vs Ce	0.09, 0.809 (−0.187–1.806)	0.14, 0.408 (−0.199–1.016)	0.30, 0.103 (− 0.128–0.334)
INH (O2 depletion)	Ug vs Be	0.13, −0.023 (−0.057–0.010)	0.17, 0.053 (−0.032–0.138)	0.02, 0.094 (0.019–0.169)*
	Ug vs Ce	0.20, 0.025 (−0.018–0.069)	0.14, 0.408 (−0.199–1.016)	0.55, 0.027 (−0.083–0.137)
		1x MIC (Ug-1 μg/ml, Be-0.121 μg/ml, Ce-0.12 μg/ml)	2x MIC (Ug-2 μg/ml, Be-0.24 μg/ml, Ce-0.24 μg/ml)	5x MIC (Ug-5 μg/ml, Be-0.6 μg/ml, Ce-0.6 μg/ml)
RIF (aerobic)	Ug vs Be	0.93, 0.006 (−0.162–0.174)	0.12, −0.427 (1.025–0.169)	0.60, −0.603 (−0.603–0.391)
	Ug vs Ce	0.34, −0.176 (−0.617–0.263)	0.07, 0.485 (−0.081–1.052)	0.49, 0.140 (−0.348–0.629)
RIF (O2 depletion)	Ug vs Be	0.51, −0.040 (−0.187–0.107)	0.36, 0.011 (−0.018–0.041)	0.004, −2.137 (−3.277–0.996)*
	Ug vs Ce	0.13, 0.073 (−0.033–0.179)	0.01, 0.036 (0.009–0.063)*	0.005, 2.230 (0.997–3.463)*

MIC, minimum inhibitory concentration; Ug, Uganda II; Ce, Delhi/CAS; Be, Beijing

INH, Isoniazid; RIF, Rifampicin;

*P-value <0.05