Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 21;15:29. doi: 10.1186/s12943-016-0513-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Wilkinson et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 2 — Compound 6 reduces MC38 CTSS-like activity and blocks intracellular degradation of CD74. a MC38 cells were lysed and treated with compound 6 demonstrating reduction of CTSS-like activity b) Compound 6 permeated the cell membrane of human Raji cells and blocked degradation of CD74 fragment lip10, a canonical endosomal CTSS substrate. c Evaluation of lip10 band intensity revealed an IC₅₀ value of 2.9 µM for compound 6