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. Author manuscript; available in PMC: 2017 Mar 18.

Published in final edited form as: Curr Protoc Pharmacol. 2016 Mar 18;72:9.19.1–9.19.19. doi: 10.1002/0471141755.ph0919s72

Fig. 9.19.11 — A self-administration score (determined from injections per session) in monkeys is shown as smoothed dose-effect curves for remifentanil (upper) and cocaine (lower). Equations from nonlinear regression are for remifentanil $E = \frac{12.2 D^{2.53}}{D^{2.53} + {0.163}^{2.53}}$ , and for cocaine $E = \frac{19.02 D}{D + 37.4}$ . The effect = one half the cocaine maximum (9.51) is used to derive the isobole shown in Figure 9.19.12. The isobole for effect 9.51 is derived by substitution with the drug pair parameters and is given below to show the calculation detail. This form of the isobole Eq. [14] has p = 1 and q = 2.53.

Fig. 9.19.11 — A self-administration score (determined from injections per session) in monkeys is shown as smoothed dose-effect curves for remifentanil (upper) and cocaine (lower). Equations from nonlinear regression are for remifentanil $E = \frac{12.2 D^{2.53}}{D^{2.53} + {0.163}^{2.53}}$ , and for cocaine $E = \frac{19.02 D}{D + 37.4}$ . The effect = one half the cocaine maximum (9.51) is used to derive the isobole shown in Figure 9.19.12. The isobole for effect 9.51 is derived by substitution with the drug pair parameters and is given below to show the calculation detail. This form of the isobole Eq. [14] has p = 1 and q = 2.53.