a |
dose of drug A |
A |
dose of drug A that gives a specified effect |
A50 |
dose of drug A that gives half of its maximum effect |
Aeq(b) |
drug A equivalent of dose (b) of drug B |
Ai |
most general designation for dose of drug A that gives effect level i |
b |
dose of drug B |
B |
dose of drug B that gives a specified effect |
B50 |
dose of drug B that gives half of its maximum effect |
Beq(a) |
drug B equivalent of dose (a) of drug A |
Bi |
most general designation for dose of drug B that gives effect level i
|
C |
potency constant in common dose response equation |
D |
dose |
D50 |
Dose of a drug that gives half its maximum response |
DRC |
Dose-response curve |
E |
Effect |
ED50 |
Dose that is effective in 50% of subjects |
Emax |
Maximum effect of a drug |
f(a) |
g − 1 + gA/a, a simplifying term |
Fa |
fractional effect due to dose a of drug A |
Fb |
fractional effect due to dose b of drug B |
Fab |
fractional effect due to combination (a,b) dose |
g |
ratio Emax(b)/Emax(a) |
p |
exponent (on dose) in dose-response equation |
q |
exponent (on dose) in dose-response equation |
pA |
proportion of the quantity (total dose) that is drug A in a combination |
pB |
proportion of the quantity (total dose) that is drug B in a combination |
Var |
variance |
Zadd |
Total drug quantity in an additive combination |