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(A) HER2-targeting monoclonal antibody trastuzumab in scFv-Fc format was engineered with or without selenocysteine (Sec) or cysteine (Cys) resulting in four different constructs, scFv-Fc, scFv-Fc-Sec, scFv-FcS396C, and scFv-FcS396C-Sec. Engineered Sec and Cys enabled site-specific modification of the antibody with dual modalities. (B) Structures of methylsulfone-ODA-fluorescein and biotin-ethylenediamine-iodoacetamide.
