Table 2.
Associations between methylation at three CpG sites at HIF3A and BMI
| Childhood | Adolescence | |||||||
|---|---|---|---|---|---|---|---|---|
| Basic model (n = 970)* | Adjusted model (n = 918)† | Basic model (n = 845)‡ | Adjusted model (n = 804)† | |||||
| Percentage change in BMI§ | P value | Percentage change in BMI§ | P value | Percentage change in BMI§ | P value | Percentage change in BMI§ | P value | |
| cg22891070 | 0.44 (−0.35, 1.23) | 0.27 | 0.45 (−0.32, 0.12) | 0.25 | 0.66 (−0.31, 1.63) | 0.19 | 0.30 (−0.67, 1.28) | 0.54 |
| cg27146050 | 0.62 (−1.69, 2.93) | 0.60 | 0.34 (−1.89, 2.56) | 0.77 | 4.66 (1.04, 8.29) | 0.01 | 3.49 (−0.12, 7.10) | 0.06 |
| cg16672562 | 0.31 (−0.32, 0.93) | 0.34 | 0.32 (−0.29, 0.93) | 0.30 | 0.40 (−0.41, 1.20) | 0.34 | 0.24 (−0.56, 1.05) | 0.55 |
Data are % (95% CI) unless stated otherwise.
*Childhood analyses are adjusted for age, sex, and batch.
†Adolescent analyses are adjusted for age, sex, smoking, and batch.
‡Basic model additionally adjusted for smoking, alcohol, maternal education, social class, maternal smoking, maternal alcohol, birth weight, and gestational age.
§Coefficients have been converted into percentage change in BMI for every 0.1 unit increase in methylation β-value.