Table 4.
Mendelian randomization analysis for associations between adolescent BMI and methylation at cg27146050
| IV | Exposure | Outcome (O) | Observed association between IV and O (c)* | Expected association between IV and O (a × b) |
Difference between observed (c) and expected (a × b) estimates |
|
|---|---|---|---|---|---|---|
| N | β (95% CI) | β (95% CI) | P value | |||
| Adolescent cis-SNP score | Adolescent methylation at cg27146050 | Adolescent log BMI | 831 | −0.0381 (−0.2937, 0.2176) | 0.1027 (0.0315, 0.1739) | 0.30 |
| Adolescent standardized 97 SNP allele score | Adolescent log BMI | Adolescent methylation at cg27146050 | 849 | 0.0014 (−0.0009, 0.0037) | 0.0008 (0.0002, 0.0013) | 0.55 |
*Analyses are adjusted for bisulfite conversion batch only.