Fig. 2. (a) Structure of the HIF-1α CTAD/p300 CH1 domain complex (PDB ID: 1L8C,32 p300 green, HIF-1α, blue) together with 3-O-alkylated aromatic oligoamide helix mimetics for helix 2 and 3 of HIF-1α designed on the basis of (b) binding studies reported previously (regions confirmed to contribute affinity shown in purple and other regions shown in blue) (c) Modelling of helix 2 mimetic (hot spot residues on helix (in blue) are highlighted).
