Table 1. Compounds targeted to HIF-1α helix 3 binding site on p300 prepared in this study. R groups refer to Fig. 1 mimetic A .

^aNitro ester compounds obtained from 6a–c; (PPh₃)₄Pd, TolSO₂Na.

^bFollowing Route A (Scheme 3); 1. DIAD, PPh₃, ROH, 2. H₂, Pd(C), 3. NaOH.

^cFollowing Route B (Scheme 3); 1. H₂, Pd(C), 2. NaH, alkyl halide, 3. NaOH.