Skip to main content
. Author manuscript; available in PMC: 2016 Apr 21.
Published in final edited form as: Adv Cancer Res. 2014;121:183–233. doi: 10.1016/B978-0-12-800249-0.00005-6

Table 5.1.

Summary of chromatin remodeling subunits identified with probable or potential driver somatic mutations in human tumors

Remodeling
family		 Subunit Mutated cancer tissue types Complexes
SWI/SNF
family		 WSTF Large intestine, cervix, endometrium WINAC,
b-WICH,
WICH
ARID1A Skin, esophagus, stomach, biliary tract,
large intestine, cervix, endometrium,
liver, ovary, urinary tract, lung		 WINAC, BAF
BRG1 Autonomic ganglia, esophagus, lung,
urinary tract, large intestine,
endometrium		 WINAC, PBAF,
BAF
ARID2 Skin, esophagus, large intestine,
cervix, endometrium, liver, lung		 PBAF
BAF180 Endometrium, kidney PBAF
INO80
family		 SRCAP Large intestine, cervix, bone,
endometrium, lung, urinary tract		 SRCAP
CHD family CHD3 Cervix, endometrium NURD
CHD4 Stomach, endometrium NURD
CHD7 Large intestine, cervix, endometrium,
lung, urinary tract		 CHD7
CHD8 Large intestine, cervix, endometrium CHD8
ISWI family Tip5 Cervix, endometrium NoRC
SAP55 Hematopoietic and lymphoid tissue,
endometrium, thyroid		 b-WICH

Subunits of chromatin remodeling complexes whose somatic mutation was identified as a probable or potential driver of human cancer are shown (Kandoth et al., 2013; Tamborero et al., 2013). The tissues in which the gene encoding the subunit was mutated in greater than 5% of the sequenced tumors from the COSMIC database are shown. Known chromatin remodeling complexes that each subunit can assemble into are also listed.