Table 5.2.
Summary of chromatin remodeling subunits identified with frequent deregulated expression in human tumors
| Remodeling family |
Subunit | Overexpressed | Underexpressed | Complexes |
|---|---|---|---|---|
| SWI/SNF family |
CAF1 | Cervix | WINAC | |
|
| ||||
| BAF180 | Melanoma | PBAF | ||
|
| ||||
| Arid2 | Lung | PBAF | ||
|
| ||||
| Acta1 | Lymphoma, pancreatic |
PBAF, BAF | ||
|
| ||||
| BAF45b | Melanoma | PBAF, BAF | ||
|
| ||||
| BAF53b | Brain | PBAF, BAF | ||
|
| ||||
| BAF45c | Colon | PBAF, BAF | ||
|
| ||||
| BAF155 | Melanoma, liver |
WINAC, PBAF, BAF |
||
|
| ||||
| BAF57 | Bladder | WINAC, PBAF, BAF |
||
|
| ||||
| BRG1 | Melanoma, myeloma, liver, bladder |
WINAC, PBAF, BAF |
||
|
| ||||
| BRM | Ovarian | WINAC, PBAF, BAF |
||
|
| ||||
| BAF53a | Cervix | WINAC, PBAF, BAF, Tip60/p400, SRCAP INO80 |
||
|
| ||||
| INO80 family |
SRCAP | Pancreatic | SRCAP | |
|
| ||||
| Amida | Melanoma | INO80 | ||
|
| ||||
| IES2 | Bladder | INO80 | ||
|
| ||||
| IES6 | Esophagus | INO80 | ||
|
| ||||
| INO80 | Leukemia | INO80 | ||
|
| ||||
| YY1 | Melanoma | INO80 | ||
|
| ||||
| EPC1 | Leukemia | Tip60/p400 | ||
|
| ||||
| MRGBP | Colon, bladder |
Tip60/p400 | ||
|
| ||||
| TIP60 | Melanoma, myeloma |
Tip60/p400 | ||
|
| ||||
| TRRAP | Myeloma | Tip60/p400 | ||
|
| ||||
| YL-1 | Liver | Tip60/p400, SRCAP |
||
|
| ||||
| RUVBL2 | Myeloma, bladder |
INO80, Tip60/ p400, SRCAP |
||
|
| ||||
| RUVBL1 | Colon | INO80, Tip60/ p400, SRCAP |
||
|
| ||||
| CHD family | CHD4 | Melanoma, myeloma |
NURD | |
|
| ||||
| MTA3 | Lung | NURD | ||
|
| ||||
| MBD2 | Esophagus | NURD | ||
|
| ||||
| GATAD2B | Leukemia | NURD-Like | ||
|
| ||||
| CHD7 | Liver | Lymphoma | CHD7 | |
|
| ||||
| ISWI family | BPTF | Myeloma | Lymphoma | NURF |
|
| ||||
| DEK | Cervix | b-WICH | ||
|
| ||||
| DDX21 | Colon | b-WICH | ||
|
| ||||
| ACF1 | Kidney | CHRAC, ACF | ||
|
| ||||
| RBAP48 | Melanoma | NURF, NURD | ||
|
| ||||
| SNF2L | Ovarian | NURF, RSF, CERF |
||
Subunits of chromatin remodeling complexes whose expression is deregulated in at least 20% of the unique analyses from each tissue type from Fig. 5.4 are listed. Known chromatin remodeling complexes that each subunit can assemble into are also listed.