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. 2015 Oct 29;5(3):e1091555. doi: 10.1080/2162402X.2015.1091555

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 5. — T cells infiltrated into subcutaneous xenograft tumors in response to 6PHU3 have an activated and cytotoxic functional status. (A) Injection schedule scheme. (B) Flow cytometric analysis of human T cells in whole tumor tissue. Percentage of TILs from gated live singlet total cells is depicted. Significance was calculated by comparing PBMC/6PHU3 to PBMC/ctrl bi-(scFv)₂ and to PBMC/vehicle. (C) Heatmap showing a log2-fold expression of PBMC/ctrl bi-(scFv)₂ (‘PBMC/ctrl’) and PBMC/6PHU3 groups with respect to PBMC/vehicle group as reference (mean values of two independent runs). Gene expression was evaluated using a predesigned primer panel specific for 46 human T-cell identification-markers as measured by Fluidigm. Ns indicates not significant; T_CM, central memory T cells; T_EM, effector memory T cells; T_EMRA, CD45RA⁺ effector memory T cells; T_N, naive T cells; T_reg, regulatory T cells; *p < 0.03; **p < 0.008; ***p < 0.0009.