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Molecular mechanism of β-catenin-driven immune escape. β-catenin-mediated immune avoidance occurs via inhibition of CCL4 production by the tumor cells themselves, as a result of induction of the transcriptional repressor ATF3, which blocks CCL4 gene transcription (see right zoom-in panel). This lack of CCL4-secretion results in failed recruitment of CD103+ dendritic cells, thereby preventing cross-priming of antitumor T cells (indicated on left overview panel).
