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. 2015 Nov 10;5(3):e1100791. doi: 10.1080/2162402X.2015.1100791

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — T cell subset functional alterations observed in periphery during breast tumor progression. The functionality of T cell subsets was assessed on WB after short-term polyclonal stimulation (P/I) in presence of brefeldin A in cohorts of patients with breast cancer at different stages of disease (PT (n = 46), FR (n = 34), SR (n = 20)) and compared to a HD cohort (=31) and presented as percentage of cell subsets producing a specified cytokine in the different cohorts: percentage of IL-2 production by CD4⁺ (A) and CD8⁺ (B) T cell subsets (CD45RA⁺ and CD45RA^neg), percentage of IFNγ production by CD4⁺ (C) and CD8⁺ (D) T cell subsets (CD45RA⁺ and CD45RA^neg) and (E) percentage of IL2 and IFNγ and IL2 and TNFα (F) co-production by CD45RA^neg memory CD4⁺ and CD8⁺ T cells. *: p value <0.05, **: p value <0.01, ***: p value <0.001, ****: p value <10⁻⁴.