Figure 2.
vvDD-CXCL11 treatment elicited antitumor effects in AB12-luc tumor model. AB12-luc cells (4 × 105) were inoculated i.p. into BALB/c mice and injected i.p. with PBS, vvDD or vvDD-CXCL11 (1 × 108 pfu/mouse) 5 d post tumor cell inoculation. (A). Tumor burden was measured by in vivo bioluminescence imaging on days 5 (D5) and 18 (D18) post tumor cell inoculation (n = 10 per group; only five mice per group are shown). One mouse (#4) in the PBS treated group has died of tumor burden on day 17, thus no image on D18. (B). Animal survival in AB12-luc tumor-bearing mice is presented using Kaplan–Meier survival curves. The curves represented data pooled from three independent experiments (n = 28 or more as indicated). p values are presented in the context of Results.