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. 2016 Mar 21;113(15):E2180–E2188. doi: 10.1073/pnas.1515941113

Fig. 4.

Fig. 4.

Dopaminergic SNc neurons in parkinsonian mice do not reliably represent movement onset in their firing rates. (A and C) Examples of single-unit activities and PETHs from identified dopaminergic SNc neurons in 2-year-old Snca−/− littermate controls (A) and SNCA-OVX parkinsonian mice (C). (B and D) Mean PETHs show that, on average, the firing rate of SNc neurons in Snca−/− mice (n = 11 neurons) decreased significantly at movement onset (B), but there was no significant change in the firing rate of SNc neurons in SNCA-OVX mice (n = 12 neurons) (D). (E) Mean ISIs of neurons in Snca−/− mice during the baseline, premovement, and movement periods (defined as in Fig. 1); ISIs were significantly longer during movement than at baseline (P < 0.001, n = 8 neurons, one-way repeated-measures ANOVA with Dunnett’s post hoc comparison). (F) ISIs were not significantly different in SNCA-OVX parkinsonian mice (P > 0.05, n = 6 neurons, one-way repeated-measures ANOVA). (G) Schematic coronal sections denoting locations of recorded and labeled neurons within the SNc [n = 13 neurons from Snca−/− mice (red) and 14 neurons from SNCA-OVX mice (green)]. Data are presented as mean ± SEM; ***P < 0.001; ns, not significant.