Fig. S5.

Computational modeling predicts that the movement-related firing of VTA dopaminergic neurons will lead to a peak in dopamine release in the nucleus accumbens during movement. (A) Schematic illustrating the region in which dopamine release and receptor activity were modeled using spike trains recorded from VTA neurons. DS, dorsal striatum; NAc, nucleus accumbens. (B–D) Movement-related changes (mean PETH ± SEM) in dopamine concentration (B), in the activity of low-affinity D1 dopamine receptors (C), and in the activity of high-affinity D2 dopamine receptors (D) in the nucleus accumbens.