Table 1.

Data collection and refinement statistics

Parameters	σS-TIC1	σS-TIC2 1-h soaking with CTP only	σS-TIC3 1-h soaking with CTP, UTP, and GTP
Data collection
Space group	P212121	P212121	P212121
Cell dimensions, Å
a	131.71	132.75	132.87
b	152.67	151.97	152.17
c	226.70	228.06	229.12
Resolution, Å	100–3.60 (3.66–3.60)	100–4.20 (4.27–4.20)	100–4.60 (4.68–4.60)
Rsym, %	12.5 (>100)	10.2 (>100)	8.5 (>100)
I/σI*	9.87 (0.37)	8.44 (0.46)	10.06 (0.55)
Completeness, %	99.6 (99.4)	99.9 (100)	99.3 (99.6)
Redundancy	5.1 (4.2)	7.7 (7.9)	6.9 (6.8)
Refinement
Resolution, Å	100–3.60	100–4.20	100–4.60
No. reflections	50,952	32,692	24,772
Rwork/Rfree, %	24.7/28.7	26.7/32.7	24.0/33.4
No. atoms	27,632	29,036	29,036
Protein	26,167	27,572	27,572
DNA/RNA/ions	1,465	1,464	1,464
B factors	129.5	177.4	183.1
Rmsd
Bond length, Å	0.011	0.011	0.008
Bond angle, °	1.448	1.422	1.179

Values in parentheses are for highest-resolution shell. Each dataset was collected from a single crystal.

^*I/σI = 2.0 at 4.2 Å (σ^S-TIC1), 5.6 Å (σ^S-TIC2), 6.2 Å (σ^S-TIC3); I/σI = 1.0 at 3.9 Å (σ^S-TIC1), 4.7 Å (σ^S-TIC2), 5.2 Å (σ^S-TIC3).