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OPTN–TBK1 complex formation is blocked by ALS-associated human mutations. Immunofluorescence of HeLa cells stably expressing HA-Parkin. Cells were transfected with GFP–TBK1 WT or E696K for 48 h and treated with CCCP for 105 min. Individual and merged images show mitochondria (blue), Parkin (red), and TBK1 (green).
