Table 1.
Overview of miRNAs that are involved in antineoplastic effects of 1,25(OH)2D3
| microRNA | Cell Type | Regulation by 1,25(OH)2D3 | Target of microRNA | Biological Effect | Reference Nos. |
|---|---|---|---|---|---|
| miR-22 | Colon cancer, SW480-ADH, and HCT116 cell lines | Increased expression | Implicated in antiproliferative and antimigratory effect of 1,25(OH)2D3 | 17 | |
| miR-27b mmu-miR-298 | Colon adenocarcinoma LS-180 and pancreatic PANC1 cell lines | Not investigated | VDR | Overexpression of miR-27b and mmu-miR-298 results in reduced VDR protein levels | 349 |
| miR-27b | Melanoma SK-Mel5, SK-Mel28, and IGR cell lines | Reduced expression in conjunction with 5-azacytidine | VDR | Reduced miR-27b expression correlates with increased VDR mRNA | 135 |
| miR-32 | Human myeloid leukemia HL60 and U937 cells | Increased expression | BIM | Implicated in apoptotic cell death after 1,25(OH)2D3 treatment | 167 |
| miR-98 | Prostate cancer LNCaP cells | Increased expression | CCNJ | Implicated in the antiproliferative effect of 1,25(OH)2D3 | 445 |
| miR-100 miR-125b | Prostate cancer RWPE-2 cell line | Increased expression | E2F3, PLK1 | Implicated in decreased proliferation and migration after 1,25(OH)2D3 treatment | 163 |
| miR-125b | Human breast MCF7 cell line | Not investigated | VDR, CYP24A1 | Mature miR-125 levels negatively correspond to decreased VDR protein Overexpression of miR-125b leads to reduced antiproliferative effect of 1,25(OH)2D3 CYP24 protein levels in cancer tissues are inversely associated with their miR-125b levels | 315 |
| miR-125b | Melanoma MeWo and SK-Mel28 cell lines | Not investigated | VDR | VDR protein levels are inversely associated with miR125b levels | 135 |
| miR-145 | Gastric SGC-7901 and AGS cell line | Increased expression | E2F3 | Implicated in the antiproliferative effect of 1,25(OH)2D3 | 75 |
| miR-181a miR-181b | Human myeloid leukemia HL60 and U937 cells | Reduced expression | p27KIP1 | Regulation of miR-181a is implicated in the differentiation inducing effect of 1,25(OH)2D3 | 476 |
| miR-302c miR-520c | Hematological tumor Kasumi-1 and breast cancer MDA-MB-231 cell line | Reduced expression | MICA/B and ULBP2 (NKG2D ligands) | Implicated in the immuno-attack of NK cells against malignant cells | 313 |
| miR-498 | Various ovarian, endometrium, and breast cancer cell lines | Increased expression | TERT | Implicated in decreased cell proliferation after 1,25(OH)2D3 treatment | 224 |
| miR-627 | Colorectal HT29 cell line | Increased expression | JMJD1A | Increased methylation of histone H3K9, Suppressed expression of proliferative factors | 346 |